CDK 4/6 Drug Interactions
Last Reviewed March 2025
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Palbociclib Interactions
Lisdexamphetamine
No clinically significant drug interactions identified.
Lisinopril
No clinically significant drug interactions identified.
Loperamide
No clinically significant drug interactions identified.
Lorazepam
No clinically significant drug interactions identified.
Losartan
No clinically significant drug interactions identified.
Medroxyprogesterone
No clinically significant drug interactions identified.
Memantine
No clinically significant drug interactions identified.
Metformin
No clinically significant drug interactions identified.
Methadone
Caution - increased level of methadone due to 3A4 inhibition. Monitor for signs of toxicity (sedation, confusion, dizziness). If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Methimazole
No clinically significant drug interactions identified.
Methylphenidate
No clinically significant drug interactions identified.
Metoclopramide
No clinically significant drug interactions identified.
Metoprolol
No clinically significant drug interactions identified.
Metrondiazole
No clinically significant drug interactions identified.
Mirtazapine
No clinically significant drug interactions identified.
Misoprostol
No clinically significant drug interactions identified.
Montelukast
No clinically significant drug interactions identified.
Morphine
No clinically significant drug interactions identified.
Moxifloxacin
No clinically significant drug interactions identified.
Naltrexone
No clinically significant drug interactions identified.
Naproxen
No clinically significant drug interactions identified.
Nifedipine ER
No clinically significant drug interactions identified.
Nitrofurantoin
No clinically significant drug interactions identified.
Nortriptyline
No clinically significant drug interactions identified.
Olanzapine
No clinically significant drug interactions identified.
Omeprazole
No clinically significant drug interactions identified.
Ondansetron
No clinically significant drug interactions identified.
Orlistat
No clinically significant drug interactions identified.
Oxazepam
No clinically significant drug interactions identified.
Oxybutynin
No clinically significant drug interactions identified.
Oxycodone
Caution - increased level of oxycodone due to 3A4 inhibition. Monitor for signs of toxicity (sedation, confusion, dizziness). If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Pantoprazole
No clinically significant drug interactions identified.
Paroxetine
No clinically significant drug interactions identified.
Penicillin V
No clinically significant drug interactions identified.
Perindopril
No clinically significant drug interactions identified.
Phenobarbital
Avoid combination - decreased level of palbociclib due to 3A4 induction. Choose an alternative agent.
Phenytoin
Avoid combination - decreased level of palbociclib due to 3A4 induction. Choose an alternative agent.
Pioglitazone
No clinically significant drug interactions identified.
Pravastatin
No clinically significant drug interactions identified.
Prazosin
No clinically significant drug interactions identified.
Prednisone
No clinically significant drug interactions identified.
Pregabalin
No clinically significant drug interactions identified.
Prochlorperazine
No clinically significant drug interactions identified.
Propranolol
No clinically significant drug interactions identified.
Quetiapine
No clinically significant drug interactions identified.
Rabeprazole
No clinically significant drug interactions identified.
Ramipril
No clinically significant drug interactions identified.
Ranitidine
No clinically significant drug interactions identified.
Repaglinide
No clinically significant drug interactions identified.
Risedronate
No clinically significant drug interactions identified.
Risperidone
No clinically significant drug interactions identified.
Rivaroxaban
No clinically significant drug interactions identified.
Rivastigmine
No clinically significant drug interactions identified.
Rizatriptan
No clinically significant drug interactions identified.
Ropinirole
No clinically significant drug interactions identified.
Rosuvastatin
No clinically significant drug interactions identified.
Sacubitril/Valsartan (Entresto)
No clinically significant drug interactions identified.
Saxagliptin
No clinically significant drug interactions identified.
Semaglutide
No clinically significant drug interactions identified.
Sennosides
No clinically significant drug interactions identified.
Sertraline
No clinically significant drug interactions identified.
Sildenafil
No clinically significant drug interactions identified.
Simvastatin
Caution - increased level of simvastatin due to 3A4 inhibition. Monitor for signs of toxicity. If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Sitagliptin
No clinically significant drug interactions identified.
Solifenacin
No clinically significant drug interactions identified.
Spironolactone
No clinically significant drug interactions identified.
Sulfamethoxazole/ trimethoprim
No clinically significant drug interactions identified.
Sumitriptan
No clinically significant drug interactions identified.
Tadalafil
No clinically significant drug interactions identified.
Tamsulosin
No clinically significant drug interactions identified.
Telmisartan
No clinically significant drug interactions identified.
Temazepam
No clinically significant drug interactions identified.
Ticagrelor
No clinically significant drug interactions identified.
Trazodone
No clinically significant drug interactions identified.
Venlafaxine
No clinically significant drug interactions identified.
Verapamil
Caution - increased level of both agents due to 3A4 inhibition. Monitor for signs of toxicity. Consider choosing an alternative agent.
Zopiclone
No clinically significant drug interactions identified.
