Drug Interactions
Darolutamide Interactions
Acetylsalicylic acid
No clinically significant drug interactions identified.
Alprazolam
No clinically significant drug interactions identified.
Amitriptyline
No clinically significant drug interactions identified.
Amlodipine
No clinically significant drug interactions identified.
Amoxicillin
No clinically significant drug interactions identified.
Amoxicillin/clavulanate
No clinically significant drug interactions identified.
Apixaban
Avoid combination - increased level of apixaban due to BCRP/Pgp inhibition. Choose an alternative agent.
Atenolol
No clinically significant drug interactions identified.
Atorvastatin
Avoid combination - increased level of atorvastatin due to BCRP and OAT1B1/1B3 inhibition. Choose an alternative agent.
Azithromycin
No clinically significant drug interactions identified.
Bisoprolol
No clinically significant drug interactions identified.
Canagliflozin
No clinically significant drug interactions identified.
Candesartan
No clinically significant drug interactions identified.
Carbamazepine
Avoid combination - decreased level of darolutamide due to 3A4/Pgp/UGT1A1 induction. Choose an alternative agent.
Carvedilol
No clinically significant drug interactions identified.
Chlorthalidone
No clinically significant drug interactions identified.
Ciprofloxacin
No clinically significant drug interactions identified.
Citalopram
No clinically significant drug interactions identified.
Clarithromycin
Avoid combination increased level of darolutamide due to 3A4/Pgp inhibition. Choose an alternative agent.
Clomipramine
No clinically significant drug interactions identified.
Clonazepam
No clinically significant drug interactions identified.
Clopidogrel
No clinically significant drug interactions identified.
Codeine
No clinically significant drug interactions identified.
Dabigatran
No clinically significant drug interactions identified.
Dapagliflozin
No clinically significant drug interactions identified.
Degarelix
No clinically significant drug interactions identified.
Desipramine
No clinically significant drug interactions identified.
Dexamethasone
No clinically significant drug interactions identified.
Dexlansoprazole
No clinically significant drug interactions identified.
Diltiazem
No clinically significant drug interactions identified.
Doxycycline
No clinically significant drug interactions identified.
Duloxetine
No clinically significant drug interactions identified.
Dutasteride
No clinically significant drug interactions identified.
Edoxaban
No clinically significant drug interactions identified.
Empagliflozin
No clinically significant drug interactions identified.
Escitalopram
No clinically significant drug interactions identified.
Esomeprazole
No clinically significant drug interactions identified.
Famotidine
No clinically significant drug interactions identified.
Finasteride
No clinically significant drug interactions identified.
Fluconazole
No clinically significant drug interactions identified.
Fluoxetine
No clinically significant drug interactions identified.
Furosemide
No clinically significant drug interactions identified.
Gabapentin
No clinically significant drug interactions identified.
Gliclazide
Caution - increased level of gliclazide due to OAT inhibition. Monitor for signs of toxicity (ie. hypoglycemia). If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Glyburide
Caution - increased level of glyburide due to OAT inhibition. Monitor for signs of toxicity (ie. hypoglycemia). If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Goserelin
No clinically significant drug interactions identified.
Hydrochlorothiazide
No clinically significant drug interactions identified.
Hydromorphone
No clinically significant drug interactions identified.
Ibuprofen
No clinically significant drug interactions identified.
Irbesartan
No clinically significant drug interactions identified.
Lansoprazole
No clinically significant drug interactions identified.
Leuprolide
No clinically significant drug interactions identified.
Levofloxacin
No clinically significant drug interactions identified.
Levothyroxine
No clinically significant drug interactions identified.
Lorazepam
No clinically significant drug interactions identified.
Metformin
No clinically significant drug interactions identified.
Methadone
No clinically significant drug interactions identified.
Metoclopramide
No clinically significant drug interactions identified.
Metoprolol
No clinically significant drug interactions identified.
Mirabegron
No clinically significant drug interactions identified.
Mirtazapine
No clinically significant drug interactions identified.
Moxifloxacin
No clinically significant drug interactions identified.
Naproxen
No clinically significant drug interactions identified.
Nifedipine XL
No clinically significant drug interactions identified.
Nirapirib
Caution - increased level of niraparib due to BCRP inhibition. Monitor for signs of toxicity. If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Nortriptyline
No clinically significant drug interactions identified.
Olanzapine
No clinically significant drug interactions identified.
Olaparib
No clinically significant drug interactions identified.
Omeprazole
No clinically significant drug interactions identified.
Ondansetron
No clinically significant drug interactions identified.
Oxybutynin
No clinically significant drug interactions identified.
Oxycodone
No clinically significant drug interactions identified.
Pantoprazole
No clinically significant drug interactions identified.
Paroxetine
No clinically significant drug interactions identified.
Perinodopril
No clinically significant drug interactions identified.
Phenytoin
Avoid combination - decreased level of darolutamide due to 3A4/Pgp induction. Choose an alternative agent.
Prednisone
No clinically significant drug interactions identified.
Pregabalin
No clinically significant drug interactions identified.
Prochlorperazine
No clinically significant drug interactions identified.
Quetiapine
No clinically significant drug interactions identified.
Rabeprazole
No clinically significant drug interactions identified.
Ramipril
No clinically significant drug interactions identified.
Ranitidine
No clinically significant drug interactions identified.
Risperidone
No clinically significant drug interactions identified.
Rivaroxaban
Avoid combination - increased level of rivaroxaban due to BCRP/Pgp inhibition. Choose an alternative agent.
Rosuvastatin
Avoid combination - increased level of rosuvastatin due to BCRP and OAT1B1/1B3 inhibition. Choose an alternative agent.
Semaglutide
No clinically significant drug interactions identified.
Sertraline
No clinically significant drug interactions identified.
Sildenafil
No clinically significant drug interactions identified.
Silodosin
No clinically significant drug interactions identified.
Simvastatin
Caution - increased level of simvastatin due to OAT inhibition. Monitor for signs of toxicity. If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Sitagliptin
No clinically significant drug interactions identified.
Sulfamethoxazole-trimethoprim
No clinically significant drug interactions identified.
Tadalafil
No clinically significant drug interactions identified.
Talazoparib
Caution - increased level of talazoparib due to BCRP inhibiton. Monitor for signs of toxicity. If initiating therapy, titrate slowly. If already established on therapy, may require dose reduction. Consider choosing an alternative agent.
Tamsulosin
No clinically significant drug interactions identified.
Terazocin
No clinically significant drug interactions identified.
Ticagrelor
No clinically significant drug interactions identified.
Tolterodine
No clinically significant drug interactions identified.
Tramadol
No clinically significant drug interactions identified.
