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Chronic lymphocytic leukemia
Chronic lymphocytic leukemia
Available as 10 mg film-coated tablets. Contains lactose. Tablets should NOT be crushed or broken. Store at room temperature.
Antimetabolite
Take with or without food
If a dose is missed, patients should be instructed to take it as soon as they can if it is within 12 hours of the missed dose. If it is over 12 hours since the missed dose, patients should skip the missed dose and resume with the next scheduled dose.
Common: Infection, Immunosuppression, Lymphopenia, Fatigue, Leukopenia, Neutropenia.
Less Common: Neurotoxicity, Rash, Diarrhea, Neuropathy, Blurred vision, Autoimmune reactions, Autoimmune hemolytic anemia, Pulmonary toxicities, Hyperuricemia, Malignancy.
The adverse effects listed above are not exhaustive. Please refer to the relevant product monograph for full details.
Baseline before treatment: CBC & differential, serum creatinine, bilirubin, ALT, HBsAg, HBcoreAb.
During treatment: CBC & differential, serum creatinine.
BC Cancer. BC Cancer Drug Manual. Fludarabine. Vancouver, British Columbia: BC Cancer Agency. Available at: http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Fludarabine_monograph.pdf. Updated February 1, 2024. Accessed February 2, 2024.
Lexicomp. Fludarabine Monograph. In: Lexi-Drugs. Hudson, Ohio: Lexi-Comp, Inc. Available at: https://online-lexi-com.qe2a-proxy.mun.ca/lco/action/doc/retrieve/docid/patch_f/6920?cesid=64I76XufiLQ&searchUrl=%2Flco%2Faction%2Fsearch%3Fq%3Dfludarabine%26t%3Dname%26acs%3Dtrue%26acq%3Dfludarabi. Updated January 26, 2024. Accessed January 30, 2024.
Cancer Care Ontario. Fludarabine Monograph. Drug Formulary. Toronto, Ontario: Cancer Care Ontario. Available at: https://www.cancercareontario.ca/en/drugformulary/drugs/monograph/44176. Updated April 2023. Accessed January 22, 2024.
Berlex Canada. FLUDARA® Product Monograph. Pointe-Claire, Quebec. Updated September 18, 2014.